What You Should Know About Long-Term Effects of Cannabis Smoking

What You Should Know About Long-Term Effects of Cannabis Smoking

Introduction

Cannabis has become more widely used in recent years, especially after legalization in several countries. People often talk about its benefits—like pain relief or easing anxiety—but there’s another side to the story. A new study reveals that smoking cannabis can lead to lasting changes in the body, even after you quit.

How Cannabis Affects Your Body

Cannabis smoke contains chemicals that can change how your genes work—not by changing your DNA, but by affecting how it's read and used by the body. This process is known as “epigenetic change.” One way this happens is through something called DNA methylation. It’s like adding tiny tags to your genes that affect whether they are switched on or off.

This new research focused on older adults and looked closely at their blood to see how cannabis smoking had changed their DNA methylation. The scientists compared people who never smoked cannabis, those who used to smoke it, and those who still do.

What the Study Found

Even people who had quit smoking cannabis years ago still showed changes in their DNA methylation. In fact, over 5,900 genes were affected in both current and former cannabis users. These gene changes were linked to pathways related to aging and cancer. That means the way the body ages or develops cancer could be influenced by past cannabis use.

Interestingly, former users didn’t show a complete recovery. Their bodies still carried many of the same genetic tags as current users. So, quitting cannabis doesn’t necessarily mean your body goes back to normal—at least not right away.

Why This Matters

These changes could explain why cannabis smokers may experience long-term health risks, including increased chances of developing diseases related to aging or even certain types of cancer. While not all cannabis users will get sick, the study suggests there’s a silent impact happening at the genetic level.

Some genes affected by cannabis are involved in brain function and stress response. Others are linked to how the body handles inflammation, repairs itself, or responds to hormones. This adds a new layer to how we understand both the benefits and risks of cannabis.

Takeaway for You

If you use cannabis or are considering it, this research gives you something to think about. The body remembers. Even if you quit, the effects might linger, hidden deep in your genetic code. It doesn’t mean everyone will face health problems—but it’s a reason to be cautious.

Conclusion

Cannabis is not just a short-term decision. Its effects can last long after use has stopped, quietly changing the way your body works at a cellular level. As cannabis use becomes more common, especially among older adults, it's important to understand both the visible and invisible impacts. More research is needed, but for now, it’s wise to use with awareness.

Reference: https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-025-03634-9#

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